Endocrine Abstracts

We recently identified a group of neurons in the arcuate nucleus of the mammalian hypothalamus that co-localize three neuropeptides, kisspeptin, neurokinin B and dynorphin, each of which has been shown to play a critical role in the central control of reproduction. Growing evidence suggests that this subpopulation, abbreviated as the ‘KNDy’ subpopulation, plays a key role in mediating hormonal feedback control of GnRH secretion. KNDy cells are a major target for ster...

The mechanisms of development and progression of essential hypertension (EH) and concomitant type 2 diabetes (DM2) still remain not completely studied, so the comprehensive evaluation of the contribution of various indicators to the formation of this comorbidity have scientific interest.The aim of the study was comprehensive assessment of the variability of anthropometric, echocardiographic and biochemical parameters in patients with EH and concomitant D...

The finding of an adrenal incidentaloma warrants a careful diagnostic work-up to assess hormonal activity and potential malignancy. Current diagnostic algorithms depend largely on imaging studies, which is time-consuming, expensive and carries a health risk. Urinary steroid profiling using gas chromatography/mass spectrometry (GC/MS) might be a valuable diagnostic test for differentiating benign from malignant adrenal lesions, as adrenocortical carcinomas (ACC) often cause abn...

Background: According to western literature aerobic Gram-positive cocci are the predominant microorganisms that are isolated from diabetic foot ulcers. In contrast, whatever limited data is available from India Gram-negative aerobic bacteria were most frequently isolated.Aims and objectives: To know the clinical and microbiological profile of patients with infected diabetic foot ulcers.Patients and methods: A descriptive cross-sect...

Thyroid stunning means reduced radioiodine uptake in thyroid tissue or tumour following a diagnostic 131I test dose. This may compromise subsequent 131I radiotherapy. Recently, we found that 131I inhibits iodide uptake in cultured thyroid cells at non-lethal absorbed doses. Here, we have investigated whether 131I irradiation affects the TSH-stimulated transcription of the sodium/iodide symporter (NIS) gene, and whether insulin-like g...

Background: In-patients inadequate food intake can worsen the prevalence and degree of malnutrition.Patients and methods: A “one day” questionnaire was used in medicine (M-Dpts) geriatric (G-Dpts) and surgery (S-Dpts) departments of a university hospital to: i) evaluate nutritional status with the Detky score, ii) quantify food intake, iii) understand the reasons of non-consumption of in-patients (n 286, 46 & 104 in M-, G- & S-Dpts, res...

Background: In bariatric surgery (BS) patients, nonalcoholic fatty liver disease and fibrosis are present in up to 90% and 24%, respectively. Several fibrosis risk scores have been developed and have been validated in cohorts different from morbid obesity (MO). We aimed to determine whether established liver fibrosis scores were accurate in predicting fibrosis in MO subjects.Material and Methods: Cross-sectional analysis in a cohort of MO patients underg...

Objectives: Long-term results of medical treatment of macroprolactinoma in children and adolescents (<20 years).Patients and methods: Retrospective analysis of all the cases of macroprolactinoma occurring in children and adolescents, medically treated in two university centers.Results: 38 patients, 25 girls 13 boys, age at diagnosis: 15.7±2.8 years (only two cases before 12 years). At diagnosis, 2/3 presented with headache...

A 60-year-old gentleman who had previously undergone a right nephrectomy for renal cell carcinoma was admitted electively for a left adrenalectomy due to metastatic disease. Prior to this he had been treated with immunotherapy (Sunitinib) and radiotherapy for pulmonary and bony metastases respectively. He was given perioperative cover with hydrocortisone. A short synacthen test (SST) performed the morning after discontinuing hydrocortisone showed a baseline cortisol of 406 nmo...

IntroductionThe development of flash glucose monitoring system (FGM) has led to a change in the paradigm of diabetes control, beyond the evaluation of glycosylated hemoglobin (HbA1c). FGM allows to improve control of type 1 diabetes mellitus (T1DM) and the quality of life of patients.ObjectiveDescribe the baseline characteristics of patients with T1DM in a regional hospital in the southern area of the provinc...